Exonuclease of human DNA polymerase gamma disengages its strand displacement function
نویسندگان
چکیده
منابع مشابه
3' to 5' exonuclease activity of herpes simplex virus type 1 DNA polymerase modulates its strand displacement activity.
Using a minicircle DNA primer-template, the wild-type catalytic subunit of herpes simplex virus type 1 (HSV-1) DNA polymerase (pol) was shown to lack significant strand displacement activity with or without its processivity factor, UL42. However, an exonuclease-deficient (exo(-)) pol (D368A) was capable of slow strand displacement. Although UL42 increased the rate (2/s) and processivity of stra...
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متن کاملActivity of Herpes Simplex Virus Type 1 DNA Polymerase Modulates Its Strand Displacement Activity
Using a minicircle DNA primer-template, the wild-type catalytic subunit of herpes simplex virus type 1 (HSV-1) DNA polymerase (pol) was shown to lack significant strand displacement activity with or without its processivity factor, UL42. However, an exonuclease-deficient (exo ) pol (D368A) was capable of slow strand displacement. Although UL42 increased the rate (2/s) and processivity of strand...
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ژورنال
عنوان ژورنال: Mitochondrion
سال: 2013
ISSN: 1567-7249
DOI: 10.1016/j.mito.2013.08.003